Exercise Improves Cancer Outcomes




Patients with cancer undergo various treatments including surgery, radiation, and chemotherapy managed by oncology and related specialties. There are certain additional measures that patients can take on their own to improve symptoms and often increase longevity. Lifestyle measures include nutrition, exercise, sleep, stress management, adequate social interaction, and avoiding risky substances. These form the six pillars of Lifestyle Medicine. In addition, spiritual matters are very important.

It has been known that exercise can prevent cancer, but only recently has there been a randomized controlled trial in patients with stage III or high-risk stage II colon cancer that showed decreased mortality with regular exercise. (New England Journal of Medicine 2025: 393:13-25). These are patients whose cancer had spread through the bowel wall to nearby structures or lymph nodes but not distant spread. After surgery and chemotherapy, patients were randomized to a structured exercise program or to only receive health education materials. There was significant improvement in survival in the exercise group versus the education group, without cancer return at five years, as well as decreased mortality at almost eight years. Improvements with exercise are in addition to those seen with the primary therapies.

Exercise is safe for most patients with cancer. It is beneficial before, during, and after treatment. Regular exercise can improve muscle strength, decrease fatigue, anxiety, and depression as well as improve quality of life, strengthen the immune system, and reduce treatment side effects. (Health Quality Life Outcomes 2020: 18:197).

Mortality benefits have been seen in patients with breast, colon, and prostate cancers who exercise regularly. We recommend exercise for patients with all types of cancer to achieve the above benefits even though mortality benefits have not yet been proven. The Centers for Disease Control and Prevention recommend that adult patients have 150 minutes of moderate exercise weekly as well as two days of strength training. This works out to 30 minutes five days weekly or any amount adding up to 150. Patients do not need to perform their daily amount of exercise at one time; they can do some exercise in the morning and some in the afternoon to make up the daily total. Although these are general guidelines, they do not differ in patients who have cancer. Starting slowly is key. Begin by walking a few minutes or climbing stairs instead of riding the elevator and gradually work up to 30 minutes on most days. There is no minimum amount of exercise that can give one benefit, although the largest incremental benefit occurs in those who do none and start doing some.

Change is difficult in many circumstances, and patients need to be motivated and confident that they can indeed change. The new activities that patients undertake need to be sustainable to be effective, and they will only yield benefit if patients continue to do them.

Severe fatigue is a significant problem in many patients who are undergoing cancer treatment. As mentioned above, exercise can help with this symptom as well as other quality of life issues. Knowing that exercise may improve one’s long-term outcome is usually not enough motivation to continue physical activity. Rather, when patients see that they feel better after exercise, this will be the incentive to continue exercising.

Patients’ care teams can help them acquire the necessary motivation for exercise as well as other lifestyle measures and guide them on their individual paths. Lifestyle Medicine providers are well suited to assist patients’ primary cancer caregivers and patients to maximize their lives in quality and quantity.

 

Dr. Birnbaum practices Internal Medicine with Lifestyle Medicine and sees patients at Johns Hopkins at Water’s Edge in Belcamp, MD in Harford County.

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